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Selenium in nanoform: toxicity and safety
https://doi.org/10.57256/2949-0715-2022-1-24-32
Abstract
The review is devoted to the toxicity and safety of nanosized forms of selenium. It is shown that in nature selenium exists mainly in the form of selenate (Se6+), selenite (Se4+), selenide (Se2–) and elemental selenium (Se0), while the latter is insoluble in aqueous media, less toxic and biologically inert. In the form of nanosized particles, elemental selenium is not only biocompatible, but also has antitumor and antimicrobial activity.
It has been shown that elemental selenium in the form of nanoparticles can modulate the activity of the antioxidant and detoxification systems. A dose-dependent effect of selenium in nanosized form has been demonstrated. It has been shown that at high concentrations (above 2 mg Se per kg of animal weight) selenium nanoparticles can cause the development of selenium-induced toxicity in mammals.
It has been shown that elemental selenium in the form of nanoparticles can affect immunoregulation, reproductive function, kidney and liver function, modulate the activity of the antioxidant and detoxification systems, and in high concentrations (above 2 mg Se per kg of animal weight) cause the development of selenium-induced toxicity both in mammals and fish. At the same time, for fish, it was shown that selenium nanoparticles are more toxic than inorganic selenium and cause a more acute reaction of the body to exposure to even low concentrations, possibly associated with hyperaccumulation of selenium in tissues, which once again reminds us of the need to take into account the problems of ecotoxicity of selenium nanocomposites.
For citations:
Shurygina I., Dremina N., Trukhan I., Shurygin M. Selenium in nanoform: toxicity and safety. Baikal Medical Journal. 2022;1(1):24-32. (In Russ.) https://doi.org/10.57256/2949-0715-2022-1-24-32
The review is devoted to the toxicity and safety of nanosized forms of selenium. It is shown that in nature selenium exists mainly in the form of selenate (Se6+), selenite (Se4+), selenide (Se2–) and elemental selenium (Se0), while the latter is insoluble in aqueous media, less toxic and biologically inert. In the form of nanosized particles, elemental selenium is not only biocompatible, but also has antitumor and antimicrobial activity.
It has been shown that elemental selenium in the form of nanoparticles can modulate the activity of the antioxidant and detoxification systems. A dose-dependent effect of selenium in nanosized form has been demonstrated. It has been shown that at high concentrations (above 2 mg Se per kg of animal weight) selenium nanoparticles can cause the development of selenium-induced toxicity in mammals.
It has been shown that elemental selenium in the form of nanoparticles can affect immunoregulation, reproductive function, kidney and liver function, modulate the activity of the antioxidant and detoxification systems, and in high concentrations (above 2 mg Se per kg of animal weight) cause the development of selenium-induced toxicity both in mammals and fish. At the same time, for fish, it was shown that selenium nanoparticles are more toxic than inorganic selenium and cause a more acute reaction of the body to exposure to even low concentrations, possibly associated with hyperaccumulation of selenium in tissues, which once again reminds us of the need to take into account the problems of ecotoxicity of selenium nanocomposites.
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About the Authors
Irina A. Shurygina
Deputy Director for research of Irkutsk Scientific Center of Surgery and Traumatology
Russian Federation
Russian Federation
DSс. (Med.), professor
Natalya N. Dremina
Senior Research Officer at the Laboratory of cell technologies and regenerative medicine of Irkutsk Scientific Center of
Surgery and Traumatology
Russian Federation
Russian Federation
PhD. (Biol)
Irina S. Trukhan
ФГБНУ «Иркутский научный центр хирургии и травматологии», Иркутск
Russian Federation
Russian Federation
Michael G. Shurygin
ФГБНУ «Иркутский научный центр хирургии и травматологии», Иркутск
Russian Federation
Russian Federation
Supplementary files
Review
For citations:
Shurygina I., Dremina N., Trukhan I., Shurygin M. Selenium in nanoform: toxicity and safety. Baikal Medical Journal. 2022;1(1):24-32. (In Russ.) https://doi.org/10.57256/2949-0715-2022-1-24-32
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