COMPARATIVE LONG-TERM RESULTS OF PATENCY OF SAPHENOUS VEIN GRAFTS AND LEFT INTERNAL MAMMARY ARTERY IN THE LEFT ANTERIOR DESCENDING ARTERY DURING CORONARY ARTERY BYPASS GRAFTING ON A «BEATING HEART»
https://doi.org/10.57256/2949-0715-2026-5-3-64-71
Abstract
Relevance. The long-term success of coronary artery bypass grafting is largely determined by the late patency of bypass grafts. Among all conduits, the left internal mammary artery consistently shows the best outcomes. However, most comparative studies are based on heterogeneous institutional experiences and include both on-pump and off-pump techniques. There is a lack of large-scale, single-surgeon series comparing long-term patency of mammary and autologous vein grafts to the anterior interventricular artery using a uniform off-pump sternotomy approach.
Aim. To compare, by means of control graft angiography, the long-term patency of autologous vein aortocoronary bypasses and mammary artery bypasses to the anterior interventricular artery following off-pump coronary surgery through a median sternotomy, all performed by one surgeon.
Materials and Methods. Between September 1997 and December 2024, 7422 off-pump coronary bypass operations were performed in the department. From May 2001 onward, 6829 of these (92 %) were carried out via median sternotomy. Control angiography was undertaken in 1059 patients (15.5 %). For the present analysis, we selected 843 patients operated on by a single surgeon. Among them, 652 received an autologous vein aortocoronary graft to the anterior interventricular artery, and 191 received a mammary artery graft to the same vessel.
Results. The patency rates for mammary artery grafts at 5, 10, and 15 years were 91 %, 77 %, and 56 %, respectively, versus 88 %, 70 %, and 41 % for vein grafts. These differences were not statistically significant (p = 0.09).
Conclusion. In off-pump coronary bypass grafting to the anterior interventricular artery via sternotomy performed by a single surgeon, the long-term patency of autologous vein grafts may be comparable to that of mammary artery grafts.
About the Authors
Vladimir A. PodkamennyRussian Federation
Dr. Sci. (Med.), Professor, Department of Surgery, Cardiovascular Surgery, and Clinical Angiology;
cardiovascular surgeon
Aleksandr V. Eroshevich
Russian Federation
cardiovascular surgeon
References
1. Alboom M., Browne A., Sheth T. et al. Conduit selection and early graft failure in coronary artery bypass surgery: A post hoc analysis of the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) coronary artery bypass grafting study. J Thorac Cardiovasc Surg. 2023;165(3):1080-1089.e1. https://doi.org/10.1016/j.jtcvs.2022.05.028
2. Gaudino M., Di Franco A., Bhatt D.L. et al. The association between coronary graft patency and clinical status in patients with coronary artery disease. Eur Heart J. 2021;42(14):1433-1441. https://doi.org/10.1093/eurheartj/ehab096.
3. Panagiotopoulos I., Leivaditis V., Sawafta A. et al. The choice of conduits in coronary artery bypass surgery. Arch Med Sci Atheroscler Dis. 2023;8:e83-e88. https://doi.org/10.5114/amsad/170215
4. Gaudino M., Di Franco A., Bhatt D.L. et al. The association between coronary graft patency and clinical status in patients with coronary artery disease. Eur Heart J. 2021;42(14):1433-1441. https://doi.org/10.1093/eurheartj/ehab096
5. Loop F.D., Lytle B.W., Cosgrove D.M. et al. Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events. N Engl J Med. 1986;314(1):1-6. https://doi.org/10.1056/NEJM198601023140101
6. Lytle B.W., Loop F.D., Cosgrove D.M. Fifteen hundred coronary reoperations. Results and determinants of early and late survival. J Thorac Cardiovasc Surg 1987;93:847–59. URL: https://www.jtcvs.org/article/S0022-5223(19)37045-X/pdf [accessed 13.04.2026] PMID: 3494885
7. Sabik J.F. 3rd, Lytle B.W., Blackstone E.H., Khan M., Houghtaling P.L., Cosgrove D.M. Does competitive flow reduce internal thoracic artery graft patency?. Ann Thorac Surg. 2003;76(5):1490-1497. https://doi.org/10.1016/s0003-4975(03)01022-1
8. Tatoulis J., Buxton B.F., Fuller J.A. Patencies of 2127 arterial to coronary conduits over 15 years. Ann Thorac Surg. 2004;77(1):93-101. https://doi.org/10.1016/s0003-4975(03)01331-6
9. Lüscher T.F., Diederich D., Siebenmann R. et al. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med. 1988;319(8):462-467. https://doi.org/10.1056/NEJM198808253190802
10. van Son J.A., Smedts F., Vincent J.G., van Lier H.J., Kubat K. Comparative anatomic studies of various arterial conduits for myocardial revascularization. J Thorac Cardiovasc Surg. 1990;99(4):703-707. URL: https://pubmed.ncbi.nlm.nih.gov/2319794/ [accessed 13.04.2026] PMID: 2319794
11. Guida G., Ward A.O., Bruno V.D. et al. Saphenous vein graft disease, pathophysiology, prevention, and treatment. A review of the literature. J Card Surg. 2020;35(6):1314-1321. https://doi.org/10.1111/jocs.14542
12. Al-Sabti H.A., Al Kindi A., Al-Rasadi K., Banerjee Y., Al-Hashmi K., Al-Hinai A. Saphenous vein graft vs. radial artery graft searching for the best second coronary artery bypass graft. J Saudi Heart Assoc. 2013;25(4):247-254. https://doi.org/10.1016/j.jsha.2013.06.001
13. Song S.W., Sul S.Y., Lee H.J., Yoo K.J. Comparison of the radial artery and saphenous vein as composite grafts in off-pump coronary artery bypass grafting in elderly patients: a randomized controlled trial. Korean Circ J. 2012;42(2):107-112. https://doi.org/10.4070/kcj.2012.42.2.107
14. Harskamp R.E., Lopes R.D., Baisden C.E., de Winter R.J., Alexander J.H. Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. Ann Surg. 2013;257(5):824-833. https://doi.org/10.1097/SLA.0b013e318288c38d
15. Xenogiannis I., Zenati M., Bhatt D.L. et al. Saphenous Vein Graft Failure: From Pathophysiology to Prevention and Treatment Strategies. Circulation. 2021;144(9):728-745. https://doi.org/10.1161/CIRCULATIONAHA.120.052163
16. Zenati M.A., Bhatt D.L., Stock E.M. et al. Intermediate-Term Outcomes of Endoscopic or Open Vein Harvesting for Coronary Artery Bypass Grafting: The REGROUP Randomized Clinical Trial. JAMA Netw Open. 2021;4(3):e211439. https://doi.org/10.1001/jamanetworkopen.2021.1439
17. Gaudino M., Bakaeen F.G., Sandner S. et al. Expert systematic review on the choice of conduits for coronary artery bypass grafting: endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and The Society of Thoracic Surgeons (STS). Eur J Cardiothorac Surg. 2023;64(2):ezad163. https://doi.org/10.1093/ejcts/ezad163
18. Gaudino M., Hameed I., Robinson N.B. et al. Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta-Analysis of Randomized Trials. J Am Heart Assoc. 2021;10(6):e019206. https://doi.org/10.1161/JAHA.120.019206
19. Lawrie G.M., Morris G.C. Jr, Chapman D.W., Winters W.L., Lie J.T. Patterns of patency of 596 vein grafts up to seven years after aorta-coronary bypass. J Thorac Cardiovasc Surg. 1977;73(3):443-448. URL: https://pubmed.ncbi.nlm.nih.gov/320398/ [accessed 13.04.2026] PMID: 320398
20. Shah P.J., Gordon I., Fuller J. et al. Factors affecting saphenous vein graft patency: clinical and angiographic study in 1402 symptomatic patients operated on between 1977 and 1999. J Thorac Cardiovasc Surg. 2003;126(6):1972-1977. https://doi.org/10.1016/s0022-5223(03)01276-5
Review
For citations:
Podkamenny V., Eroshevich A. COMPARATIVE LONG-TERM RESULTS OF PATENCY OF SAPHENOUS VEIN GRAFTS AND LEFT INTERNAL MAMMARY ARTERY IN THE LEFT ANTERIOR DESCENDING ARTERY DURING CORONARY ARTERY BYPASS GRAFTING ON A «BEATING HEART». Baikal Medical Journal. 2026;5(3):64-71. (In Russ.) https://doi.org/10.57256/2949-0715-2026-5-3-64-71
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