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DIFFICULTIES IN DIAGNOSING MYOCARDIAL INFARCTION IN A PATIENT WITH WOLFF-PARKINSON-WHITE PHENOMENON

https://doi.org/10.57256/2949-0715-2025-4-1-29-35

Abstract

Background. The Wolf-Parkinson-White phenomenon is an electrocardiographic phenomenon caused by accessory atrioventricular pathway with ventricular preexcitation. The Wolff-Parkinson-White pattern can mimic myocardial infarction and be the cause of its overdiagnosis. At the same time, it can mask the true myocardial infarction.

The aim.  To present the diagnostic algorithm for suspected myocardial infarction in a patient with Wolf-Parkinson-White phenomenon.

Case report. A clinical case demonstrates the difficulties of diagnosis of myocardial infarction in a patient with Wolf-Parkinson-White phenomenon. A 47-year-old patient presented with chest pain radiating to his left arm. Electrocardiogram revealed a negative delta wave in leads II, III, and avF with ST segment elevation in these leads. There were positive delta waves and ST depressions and T inversions in lead I, aVL, V1-V6. Conclusion about inferior myocardial infarction with ST elevation was made. Thrombolytic therapy was performed. There was no dynamic on the electrocardiograms. The patient was transported to the Percutaneous Coronary Intervention center. Coronary angiography did not show any coronary artery stenosis. The troponin I level was normal and repeat troponin test was normal too. Echocardiography did not reveal disturbance of local contractility.

The results of the examination made it possible to exclude a myocardial infarction in the patient with Wolf-Parkinson-White phenomenon. Electrocardiography indicates a left-sided posteroseptal accessory pathway. The patient has a Wolf-Parkinson-White phenomenon, as there are no attacks of paroxysmal tachycardia.

Conclusion. This case illustrates the difficulties of diagnosis of myocardial infarction in a patient with the Wolf-Parkinson-White phenomenon and importance of assessment ECG dynamic, troponin, coronarography and echocardiography.

About the Authors

Elena Sergeevna Eniseeva
Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional Education; Irkutsk State Medical University,
Russian Federation


Tamara Mikhailovna Haltarova
Irkutsk Regional Clinical Hospital
Russian Federation


Maria Maximovna Sambarova
Irkutsk Regional Clinical Hospital
Russian Federation


References

1. Vătășescu RG, Paja CS, Șuș I, Cainap S, Moisa ȘM, Cinteză EE. Wolf-Parkinson-White Syndrome: Diagnosis, Risk Assessment, and Therapy-An Update. Diagnostics (Basel). 2024;14(3):296. https://doi.org/10.3390/diagnostics14030296.

2. Wong SW, Lim SSY. Acute Myocardial Infarction in a Patient with Wolff-Parkinson-White Pattern ECG Acta Cardiol Sin. 2023;39(4):663-666. https://doi.org/10.6515/ACS.202307_39(4).20230410A.

3. Liu R, Chang Q. The diagnosis of myocardial infarction in the Wolff-Parkinson-White syndrome. Int J Cardiol. 2013;167:1083–4. https://doi.org/10.1016/j.ijcard.2012.10.055.

4. Thomson JJ, Shah J, Charnigo R, Tackett A, Darrat YH, Bailey A, Delisle B, Kakavand B, et al. A practical ECG criterion to unmask left accessory AV connections in patients with subtle preexcitation. J Cardiovasc Electrophysiol. 2015; 26(9): 978–84. https://doi.org/10.1111/jce.12711.

5. Goldberger AL. Pseudo-infarct patterns in the Wolff-Parkinson-White syndrome: importance of Q wave-T wave vector discordance. J Electrocardiol 1980;13:115-8. https://doi.org/10.1016/s0022-0736(80)80041-0

6. Butt M.U, Patel R, Darrat YH, Morales GX, Elayi CS. Inferior wall infarct masked by “pseudo-infarct” ECG pattern. Am J Case Rep, 2018;19:685-688. https://doi.org/10.12659/AJCR.909189.

7. Rangaswamy VV, Balaji A, Ramasamy S, Manoharan S. Myocardial infarction in a patient with WPW syndrome. Lifting the veil. J Electrocardiol. 2022;74:85-87. https://doi.org/10.1016/j.jelectrocard.2022.08.005.

8. Çifci M. Masked ECG Changes in Wolff-Parkinson-White Syndrome Coexisting With Myocardial Infarction: A Case Report. Cureus. 2024;16(7):e64507. https://doi.org/10.7759/cureus.64507.

9. de Castro Jr RL, de Alcantara Lima N, da Costa Lino DO, Bannon SF. Concealed Wolff–Parkinson–White Syndrome revealed by acute coronary syndrome. Ann Noninvasive Electrocardiol. 2020;25:e12735. https://doi.org/10.1111/anec.12735.

10. Chin C-G; Chen W-T; Lin Y-K; Chung C-C; Hsieh M-H. Electrocardiographic abnormalities in a patient with pre-excitation and acute myocardial infarction undergoing percutaneous coronary intervention and ablation. Journal of the Chinese Medical Association. 2022;85(7):804-807. https://doi.org/10.1097/JCMA.0000000000000750.

11. Iqbal A, Ghazni M, Mubarik A, Zubair N, Jamal SF. The Conversion of Wolff-Parkinson-White (WPW) Pattern into WPW Syndrome in the Presence of Ischemia: A Case Report. Cureus. 2019;11(2):e4147. https://doi.org/10.7759/cureus.4147.

12. Rajendran K, Thankachan A, Sreedharan MK, Salam A. Pre-excitation syndrome presenting with acute myocardial infarction. BMJ Case Rep. 2022;15:e250667. https://doi.org/10.1136/bcr-2022-250667.

13. Mayfield JJ, Goldschlager N. Evolution of acute ST-segment elevation myocardial infarction in a patient with ventricular preexcitation. Journal of Electrocardiology. 2020;60:188–191. https://doi.org/10.1016/j.jelectrocard.2020.04.025

14. Ling KH, Ng KS. Masking of myocardial infarction ECG in a patient with Wolff-Parkinson-White syndrome. Sing Med J. 2018;59:558-9. https://doi.org/10.11622/smedj.2018130.

15. Take Y, Morita H. Fragmented QRS: what is the meaning? Ind Pacing Electrophysiol. 2012;12:213-5. https://doi.org/10.1016/s0972-6292(16)30544-7.

16. Tang X-G, Wen J, Zhang X-S, Li X-J, Jiang D-C. Acute myocardial infarction in a patient with Wolff-Parkinson-White Syndrome. J Geriatr Cardiol. 2018;15:605-608. https://doi.org/10.11909/j.issn.1671-5411.2018.09.010.

17. Inden Y, Hirai M, Takada Y, Shimizu A, Shimokata K, Yoshida Y, Akahoshi M, Kondo T, Saito H. Prolongation of activation-recovery interval over a preexcited region before and after catheter ablation in patients with Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 2001;12(8):939-45. https://doi.org/10.1046/j.1540-8167.2001.00939.x.

18. Hamriti ME, Braun M, Molatta S, Imnadze G, Khalaph M, Lucas P, Nolting JK, Isgandarova K, et al. EASY-WPW: a novel ECG-algorithm for easy and reliable localization of manifest accessory pathways in children and adults. Europace. 2023;25:600–609. https://doi.org/10.1093/europace/euac216.


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For citations:


Eniseeva E.S., Haltarova T.M., Sambarova M.M. DIFFICULTIES IN DIAGNOSING MYOCARDIAL INFARCTION IN A PATIENT WITH WOLFF-PARKINSON-WHITE PHENOMENON. Baikal Medical Journal. 2025;4(1):29-35. (In Russ.) https://doi.org/10.57256/2949-0715-2025-4-1-29-35

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ISSN 2949-0715 (Online)

Irkutsk State Medical University

Irkutsk Scientific Center for Surgery and Traumatology