ALCOHOLIC LIVER DISEASE: ISSUES OF ETIOLOGY AND THE IMPACT OF RISK FACTORS (LITERATURE REVIEW)
https://doi.org/10.57256/2949-0715-2023-2-20-29
Abstract
Alcohol consumption is one of the main causes leading to chronic liver disease. Alcoholic liver disease is a set of cascading events, consisting first of alcoholic hepatic steatosis and then mainly through alcoholic steatohepatitis, leading to cirrhosis and hepatocellular carcinoma. This review considers chronic alcohol intoxication as the main factor in the development of liver disease. Modern data on the prevalence of forms of alcoholic liver damage in Russia and in the world are presented. The role of the consumed dose of ethanol, the nature of the alcoholic beverage, as well as the pattern of alcohol consumption in the formation of liver damage is assessed, predisposing factors are presented. The leading risk factors for alcoholic liver damage are: female gender, hereditary predisposition (ethnicity), trophological status (underweight or obesity), taking certain hepatotoxic drugs, the amount and duration of alcohol consumption and the type of alcohol consumed, smoking. The presence of concomitant viral hepatitis, environmental toxico-ecological influence and prenatal intoxication also predispose to alcoholic liver damage. The article provides a detailed assessment of the role of the presented risk factors in the development of alcoholic liver damage. However, it is not possible to identify the dominant risk factor for alcoholic liver damage, since the development of liver pathology directly depends not only on the amount of alcohol consumed, but also on the individual combination of predisposing factors. Understanding the etiology of the disease and the contribution of modifiable risk factors to its development will allow the development of effective strategies aimed at reducing the incidence and mortality from liver diseases.
About the Authors
Daria A. Stepanenko
Irkutsk State Medical University
Russian Federation
Russian Federation
Tatyana V. Goma
Irkutsk State Medical University
Russian Federation
Russian Federation
Natalia M. Kozlova
Irkutsk State Medical University
Russian Federation
Russian Federation
References
1. Huang D.Q., Mathurin P., Cortez-Pinto H., Loomba R. Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Rev Gastroenterol Hepatol. 2023;20(1):37-49. https://doi.org/10.1038/s41575-022-00688-6
2. Chao A., Waitzberg D., de Jesus R.P. et al. Malnutrition and Nutritional Support in Alcoholic Liver Disease: a Review. Curr Gastroenterol Rep. 2016;18(12):65. https://doi.org/10.1007/s11894-016-0539-4
3. Teschke R. Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects. Biomedicines. 2018;6(4):106. https://doi.org/10.3390/biomedicines6040106
4. Pimpin L., Cortez-Pinto H., Negro F. et al. Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies. J Hepatol. 2018;69(3):718-735. https://doi.org/10.1016/j.jhep.2018.05.011
5. Sheron N., Chilcott F., Matthews L., Challoner B., Thomas M. Impact of minimum price per unit of alcohol on patients with liver disease in the UK. Clin Med (Lond). 2014;14(4):396-403. https://doi.org/10.7861/clinmedicine.14-4-396
6. Clinical guidelines. Alcoholic liver disease (ALD) in adults (in Russian). URL: https://cr.minzdrav.gov.ru/recomend/711_1 [accessed: 10.05.2023]
7. Maev I.V., Abdurakhmanov D.T., Andreev D.N., Dicheva D.T. Alcoholic liver disease: State-of-the-art. Terapevticheskii Arkhiv (Ter. Arkh.). 2014;86(4):108-16 (in Russian). URL: https://www.mediasphera.ru/issues/terapevticheskij-arkhiv/2014/4/030040-36602014419 [accessed: 10.05.2023]
8. Aslam A., Kwo P.Y. Epidemiology and Disease Burden of Alcohol Associated Liver Disease. J Clin Exp Hepatol. 2023;13(1):88-102. https://doi.org/10.1016/j.jceh.2022.09.001
9. Zaridze D., Brennan P., Boreham J. et al. Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths. Lancet. 2009;373(9682):2201-2214. https://doi.org/10.1016/S0140-6736(09)61034-5
10. WHO. Alcohol. URL: https://www.who.int/news-room/fact-sheets/detail/alcohol [accessed: 10.05.2023].
11. Ritchie H., Roser M. Alcohol Consumption. Our World in Data Published online at OurWorldInData.org. 2018. URL: https://ourworldindata.org/alcohol-consumption [accessed: 10.01.2023]
12. Zamyatnina E. The structure of directly related alcohol mortality In Russia from 2011 to 2021. Demographic Review. 2022;9(2):102-118 (In Russian). https://doi.org/10.17323/demreview.v9i2.16208
13. White A.M., Castle I.P., Powell P.A. et al. Alcohol-Related Deaths During the COVID-19 Pandemic. JAMA. 2022;327(17):1704-1706. https://doi.org/10.1001/jama.2022.4308
14. Klatsky A.L. Alcohol and cardiovascular diseases: where do we stand today?. J Intern Med. 2015;278(3):238-250. https://doi.org/10.1111/joim.12390
15. Lazebnik L.B., Golovanova E.V., Tarasova L.V. et al. Adult Alcoholic Liver Disease. Experimental and Clinical Gastroenterology. 2020;174(2):4-28 (In Russian). https://doi.org/10.31146/1682-8658-ecg-174-2-4-28
16. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of alcohol-related liver disease. J Hepatol. 2018;69(1):154-181. https://doi.org/10.1016/j.jhep.2018.03.018
17. Askgaard G., Leon D.A., Kjaer M.S. et al. Risk for alcoholic liver cirrhosis after an initial hospital contact with alcohol problems: A nationwide prospective cohort study. Hepatology. 2017;65(3):929-937. https://doi.org/10.1002/hep.28943
18. Hagström H. Alcohol, smoking and the liver disease patient. Best Pract Res Clin Gastroenterol. 2017;31(5):537-543. https://doi.org/10.1016/j.bpg.2017.09.003
19. Linden-Carmichael A.N., Vasilenko S.A., Lanza S.T., Maggs J.L. High-Intensity Drinking Versus Heavy Episodic Drinking: Prevalence Rates and Relative Odds of Alcohol Use Disorder Across Adulthood. Alcohol Clin Exp Res. 2017;41(10):1754-1759. https://doi.org/10.1111/acer.13475
20. Rehm J., Crépault J.F., Wettlaufer A. et al. What is the best indicator of the harmful use of alcohol? A narrative review. Drug Alcohol Rev. 2020;39(6):624-631. https://doi.org/10.1111/dar.13053
21. Novo-Veleiro I., Alvela-Suárez L., Chamorro A.J. et al. Alcoholic liver disease and hepatitis C virus infection. World J Gastroenterol. 2016;22(4):1411-1420. https://doi.org/10.3748/wjg.v22.i4.1411
22. Szantova M., Skladany L., Janicko M. et al. Questionnaire for risk factors of alcoholic and nonalcoholic fatty liver disease. Bratisl Lek Listy. 2022;123(7):496-504. https://doi.org/10.4149/BLL_2022_079
23. Ding W.X., Yang L. Alcohol and drug-induced liver injury: Metabolism, mechanisms, pathogenesis and potential therapies. Liver Res. 2019;3(3-4):129-131. https://doi.org/10.1016/j.livres.2019.11.006
24. WHO. Harmful use of alcohol kills more than 3 million people each year, most of them men. URL: https://www.who.int/ru/news/item/21-09-2018-harmful-use-of-alcohol-kills-more-than-3-million-people-each-year--most-of-them-men [accessed: 10.05.2023]
25. Nikiforov I.A., Chernobrovkina T.V., Zhovnerchuk E.V. et al. Liver damage in alcoholism (review). Profilakticheskaya meditsina. 2014;17(3):55-61 (In Russian). URL: https://www.mediasphera.ru/issues/profilakticheskaya-meditsina/2014/3/031726-61302014310 [accessed:10.05.2023]
26. Erol A., Karpyak V.M. Sex and gender-related differences in alcohol use and its consequences: Contemporary knowledge and future research considerations. Drug Alcohol Depend. 2015;156:1-13. https://doi.org/10.1016/j.drugalcdep.2015.08.023
27. Li S.Q., Wang P., Wang D.M. et al. Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice. Hum Exp Toxicol. 2019;38(1):65-81. https://doi.org/10.1177/0960327118777869
28. Chen C.H., Ferreira J.C.B., Joshi A.U. et al. Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity. EBioMedicine. 2020;55:102753. https://doi.org/10.1016/j.ebiom.2020.102753
29. Xia J., Li S., Liu S., Zhang L. Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets. MedComm (2020). 2023;4(1):e195. https://doi.org/10.1002/mco2.195
30. Hosseini N., Shor J., Szabo G. Alcoholic Hepatitis: A Review. Alcohol Alcohol. 2019;54(4):408-416. https://doi.org/10.1093/alcalc/agz036
31. Effenberger M., Widjaja A.A., Grabherr F. et al. Interleukin-11 drives human and mouse alcohol-related liver disease. Gut. 2023;72(1):168-179. https://doi.org/10.1136/gutjnl-2021-326076
32. Ivanov A.S., Garmasch I.V., Arisheva O.S. et al. Immune-inflammatory and genetic factors in the development of alcoholic liver fibrosis. Clin Pharmacol Ther 2018;27(5):30-36 (In Russian). https://doi.org/10.32756/0869-5490-2018-5-30-35
33. Ma H.Y., Yamamoto G., Xu J. et al. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020;72(5):946-959. https://doi.org/10.1016/j.jhep.2019.12.016
34. Im G.Y. Emerging Biomarkers in Alcohol-associated Hepatitis. J Clin Exp Hepatol. 2023;13(1):103-115. https://doi.org/10.1016/j.jceh.2022.07.246
35. Nikiforov A., Burygina L., Belova M., Kostyuk G. Chronic alcohol intoxication and comorbid bowel disorders (literature review). Modern Science: Actual Problems of Theory and Practice. Series: Natural and technical sciences. 2021;(5):145-150 (In Russian). https://doi.org/10.37882/2223–2966.2021.05–2.19
36. Tadokoro T., Morishita A., Himoto T., Masaki T. Nutritional Support for Alcoholic Liver Disease. Nutrients. 2023;15(6):1360. https://doi.org/10.3390/nu15061360
37. Stickel F., Datz C., Hampe J., Bataller R. Pathophysiology and Management of Alcoholic Liver Disease: Update 2016. Gut Liver. 2017;11(2):173-188. https://doi.org/10.5009/gnl16477
38. Minato T., Tsutsumi M., Tsuchishima M. et al. Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis. Mol Med. 2014;20(1):490-502. https://doi.org/10.2119/molmed.2014.00048
39. Åberg F., Färkkilä M. Drinking and Obesity: Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Interactions. Semin Liver Dis. 2020;40(2):154-162. https://doi.org/10.1055/s-0040-1701443
40. Barbería-Latasa M., Gea A., Martínez-González M.A. Alcohol, Drinking Pattern, and Chronic Disease. Nutrients. 2022;14(9):1954. https://doi.org/10.3390/nu14091954
41. Masip J., Germà Lluch J.R. Alcohol, health and cardiovascular disease. Rev Clin Esp (Barc). 2021;221(6):359-368. https://doi.org/10.1016/j.rceng.2019.07.001
42. Knott C., Bell S., Britton A. Alcohol Consumption and the Risk of Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of More Than 1.9 Million Individuals From 38 Observational Studies. Diabetes Care. 2015;38(9):1804-1812. https://doi.org/10.2337/dc15-0710
43. GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392(10152):1015-1035.https://doi.org/10.1016/S0140-6736(18)31310-2
44. Baj J., Teresiński G., Forma A. et al. Chronic Alcohol Abuse Alters Hepatic Trace Element Concentrations-Metallomic Study of Hepatic Elemental Composition by Means of ICP-OES. Nutrients. 2022;14(3):546. https://doi.org/10.3390/nu14030546
45. Saribal D., Hocaoglu-Emre F.S., Karaman F. et al. Trace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuse. Biol Trace Elem Res. 2020;193(1):7-13. https://doi.org/10.1007/s12011-019-01681-y
46. Desbrow B., Cecchin D., Jones A. et al. Manipulations to the Alcohol and Sodium Content of Beer for Postexercise Rehydration. Int J Sport Nutr Exerc Metab. 2015;25(3):262-270. https://doi.org/10.1123/ijsnem.2014-0064
47. Dopico A.M., Bukiya A.N., Bettinger J.C. Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons. Handb Exp Pharmacol. 2018;248:281-309. https://doi.org/10.1007/164_2017_78
48. Iwakiri Y., Nathanson M.H. Alcohol and calcium make a potent cocktail. J Physiol. 2017;595(10):3109-3110. https://doi.org/10.1113/JP274133
49. Grochowski C., Blicharska E., Baj J. et al. Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review. Molecules. 2019;24(7):1361. https://doi.org/10.3390/molecules24071361
50. Kennedy O.J., Roderick P., Buchanan R. et al. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Aliment Pharmacol Ther. 2016;43(5):562-574. https://doi.org/10.1111/apt.13523
51. Hou C., Zeng Y., Chen W. et al. Medical conditions associated with coffee consumption: Disease-trajectory and comorbidity network analyses of a prospective cohort study in UK Biobank. Am J Clin Nutr. 2022;116(3):730-740. https://doi.org/10.1093/ajcn/nqac148
52. Kendler K.S., Schmitt E., Aggen S.H., Prescott C.A. Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthood. Arch Gen Psychiatry. 2008;65(6):674-682. https://doi.org/10.1001/archpsyc.65.6.674
53. Билалова А.Р., Макашова В.В. Клинико-лабораторная характеристика хронических гепатитов и циррозов печени различной. Архивъ внутренней медицины. 2015;(2):8-14 [Bilalova A.R., Makashova V.V. Clinical and laboratory characteristics of chronic hepatitis and various cirrhosis of the liver. The Russian Archives of Internal Medicine. 2015;(2):8-14 (In Russian)]. https://doi.org/10.20514/2226-6704-2015-0-2-8-14
54. Hallager S., Ladelund S., Christensen P.B. et al. Liver-related morbidity and mortality in patients with chronic hepatitis C and cirrhosis with and without sustained virologic response. Clin Epidemiol. 2017;9:501-516. https://doi.org/10.2147/CLEP.S132072
55. Younossi Z., Henry L. Systematic review: patient-reported outcomes in chronic hepatitis C--the impact of liver disease and new treatment regimens. Aliment Pharmacol Ther. 2015;41(6):497-520. https://doi.org/10.1111/apt.13090
56. Marjot T., Moon A.M., Cook J.A. et al. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study. J Hepatol. 2021;74(3):567-577. https://doi.org/10.1016/j.jhep.2020.09.024
57. Sitnikova E.Yu., Ilchenko L.Yu., Fedorov I.G., Nikitin I.G. Chronic Liver Diseases and COVID-19: Database of General Hospital. The Russian Archives of Internal Medicine. 2023;13(1):57-64 (In Russian). https://doi.org/10.20514/2226-6704-2023-13-1-57-64
58. Szabo G., Saha B. Alcohol's Effect on Host Defense. Alcohol Res. 2015;37(2):159-170. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC4590613/ [accessed: 10.05.2023]
59. Ledda C., Loreto C., Zammit C. et al. Non infective occupational risk factors for hepatocellular carcinoma: A review (Review). Mol Med Rep. 2017;15(2):511-533. https://doi.org/10.3892/mmr.2016.6046
60. Zhang R., Tang Z., Xu W. et al. Risk factors and protective factors for alcohol-related liver disease: A systematic review and meta-analysis. Alcohol Clin Exp Res. 2022;46(12):2128-2136. https://doi.org/10.1111/acer.14951
61. Dam M.K., Flensborg-Madsen T., Eliasen M., Becker U., Tolstrup J.S. Smoking and risk of liver cirrhosis: a population-based cohort study. Scand J Gastroenterol. 2013;48(5):585-591. https://doi.org/10.3109/00365521.2013.777469
62. Vysokogorsky V.E., Kurch N.M. Metabolic imprinting of prenatal alcohol intoxication. 2014. Siberian Scientific Medical Journal (Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences). 2014;34(1):5-9 (In Russian). URL: https://cyberleninka.ru/article/n/metabolicheskiy-imprinting-prenatalnoy-alkogolnoy-intoksikatsii [дата доступа: 10.05.2023]
63. Liu Q., Gao F., Liu X. et al. Prenatal alcohol exposure and offspring liver dysfunction: a systematic review and meta-analysis. Arch Gynecol Obstet. 2016;294(2):225-231. https://doi.org/10.1007/s00404-016-4109-7
64. Asiedu B., Nyakudya T.T., Lembede B.W., Chivandi E. Early-life exposure to alcohol and the risk of alcohol-induced liver disease in adulthood. Birth Defects Res. 2021;113(6):451-468. https://doi.org/10.1002/bdr2.1881
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For citations:
Stepanenko D.A., Goma T.V., Kozlova N.M. ALCOHOLIC LIVER DISEASE: ISSUES OF ETIOLOGY AND THE IMPACT OF RISK FACTORS (LITERATURE REVIEW). Baikal Medical Journal. 2023;2(2):20-29. (In Russ.) https://doi.org/10.57256/2949-0715-2023-2-20-29
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