ASSESSMENT OF CONCOMITANT PATHOLOGY AND OUTCOMES OF CHRONIC HEART FAILURE OF VARIOUS ETIOLOGIES IN PATIENTS OF THE SOUTHERN REGION OF INDIA

Relevance. Сhronic heart failure is a widespread pathology due to the high incidence of hypertension and coronary artery disease. Several million new cases of heart failure are reported in India every year. However, non-ischemic CHF is an even more difficult medical and social task due to the huge variety of causes of its causation and insufficient control by the Indian practical healthcare system.

The aim: to evaluate the frequency of concomitant pathology and outcomes of chronic heart failure of various etiologies in patients of the southern region of India

Materials and methods. A prospective study was conducted on 145 patients with chronic heart failure due to ischemic heart disease and 100 patients with chronic heart failure due to other causes, who were observed at the Kerala Institute of Medical Sciences. Comparative analysis of comorbidities and prospective two-year monitoring of each patient were conducted. The frequency of hospitalizations and the outcome of chronic heart failure during the specified period and statistical associations of events with comorbidities were assessed. Data processing was performed in the Statistica 12 program.

Results. In the group of patients with ischemic heart disease, a statistically significant predominance of cases of diabetes mellitus was revealed (84 vs. 15.3%), hypertension (74.4 vs. 25.4%), dyslipidemia (73.3 vs. 26.1%), chronic kidney disease (78 vs. 22%), anemia (72.1 vs. 27.3%), hyperuricemia (36.2 vs. 13%) compared with patients with non-ischemic etiology of heart failure. Also, in the group of patients with ischemic etiology of chronic heart failure, a predominance of cases of hospitalization during the observed period was revealed: 40 and 32.3%, respectively (p=0.001). The concomitant conditions described earlier were associated with hospitalization in the group of patients with ischemic etiology of chronic heart failure. However, in the group of patients with non-ischemic etiology, a significantly higher incidence of death was observed: 34 and 40%, respectively, which had a statistical association with atrial fibrillation.

Conclusion. Patients with chronic heart failure of non-ischemic etiology have a higher mortality rate compared to patients with chronic heart failure due to ischemic heart disease. This is probably due to insufficient control of this group. A higher prevalence of rhythm disturbances associated with mortality was also noted in this group.

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