LISTERIOSIS IN THE KRASNOYARSK REGION (RUSSIAN FEDERATION), CASES REPORT STUDY

Background. Official statistics on the incidence of listeriosis do not reflect the real spread of this infection, despite the increase in the reported case numbers in different regions of Russia.

The aim of this study is to draw attention to the diagnosis of listeriosis, especially in obstetric institutions.

Materials and methods. A descriptive  case study was conducted of 8 patents with listeriosis (7 adults, 1 child) registered in 2022-2023 in the Krasnoyarsk regional hospitals. Bacteriological testing was carried out in hospital laboratories where patients were treated. Identification of isolated bacteria was carried out using Maldi-Tof on a Vitec MS (BioMerieux, France) and Microflex (Bruker, Germany) mass spectrometer.

Case descriptions. All listeriosis cases were identified during the provision of emergency medical care to hospitalized patients. 5 women were admitted to the infectious diseases department after premature complicated childbearing, including after cesarean section (n=4). All children were born with congenital developmental defects of varying severity. The neonatal listeriosis was diagnosed in 4 cases, but only one is included in official statistics. One child died 2 days after birth. Two cases were not associated with pregnancy – acute appendicitis (n=1) and severe bacterial meningitis (n=1). The results of bacteriological examination were crucial for making a diagnosis and transferring patients to an infectious diseases department. Two types of listeria were isolated from the patients: Listeria monocytogenes and L. innocua. The incidence of listeriosis was 0.15 per 100 thousand population of the region and 0.84-0.98 per 1000 postpartum women and patients in the infectious diseases department. The circumstances and time of infection were not precisely established in any of the cases.

Conclusions. The described cases confirm the relevance of modern laboratory methods  implementation and improving infection control in obstetric medical institutions and when providing medical care to immunocompromised patients.

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