bmjourБайкальский медицинский журналBaikal Medical Journal2949-0715Irkutsk State Medical University10.57256/2949-0715-2023-1-25-32bmjour-34Research ArticleОригинальные статьиOriginal articlesОСОБЕННОСТИ ЭНДОКРИННОГО ПРОФИЛЯ ПРИ ГИПЕРТРОФИЧЕСКИХ И КЕЛОИДНЫХ РУБЦАХ КОЖИFEATURES OF ENDOCRINE PROFILE IN HYPERTROPHIC AND KELOID SCARS OF SKINhttps://orcid.org/0000-0002-7759-1078КобецМаксим ВладимировичKobetsMaxim Vladimirovich

Аспирант кафедры патологической физиологии ФГБОУ ВО ИГМУ Минздрава России, г. Иркутск

kobetsmv@gmail.comФГБОУ ВО ИГМУ Минздрава РоссииРоссияIrkutsk Regional Clinical Hospital, Irkutsk, RussiaRussian Federation202310032023212532Copyright © Кобец М.В., 20232023Кобец М.В.Kobets M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bmjour.ru/jour/article/view/34Обоснование

Обоснование. Учитывая роль гормонов в регуляции процессов формирования и ремоделирования рубцов, целесообразно исследовать особенности гормонального профиля при патологических рубцах, что даст возможность повысить эффективность диагностики типа рубца и сформировать патогенетическую основу лечения гипертрофических и келоидных рубцов.

Цель работы

Цель работы: выявление особенностей гормонального профиля при гипертрофических и келоидных рубцах.

Материалы и методы

Материалы и методы. Выполнена оценка клинического состояния рубцов и исследован гормональный профиль (10 гормонов) у 90 женщин с гипертрофическими, келоидными и нормотрофическими рубцами (контроль). Кровь брали до лечения на 5–7 сутки менструального цикла. Результаты обработаны методами непараметрической статистики (Me (Q25-Q75), U-критерий при p<0,05). Корреляционные связи между гормонами определялись методом множественной регрессии при коэффициенте детерминации R2>0,7.

Результаты

Результаты. У всех пациенток с патологическими рубцами выявлено снижение уровня кортизола. Для гипертрофических рубцов характерно повышение концентрации фолликулостимулирующего гормона, снижение концентрации эстрадиола и тестостерона. У пациенток с келоидами повышена концентрация гормона роста, снижен уровень пролактина, лютеинизирующего гормона. Регрессионный анализ показал, что при нормотрофических рубцах взаимозависимость гормонов выражена максимально, тогда как при патологических рубцах показатели гормонального профиля имеют 1-2 корреляции. При этом изменяются качественный состав и направленность взаимосвязей.

Заключение

Заключение. Для патологического рубцевания характерно снижение уровня кортизола в крови, которое при келоидных рубцах более выражено в сочетании со сниженным пролактином. При гипертрофических рубцах выявлены ослабление гормональных взаимодействий и дисбаланс в системе половых гормонов, а при келоидных рубцах – высокая концентрация гормона роста и устойчивое взаимодействие стероидогенеза с ослабленной способностью к адаптации.

Background

Background. Given the role of hormones in the regulation of scar formation and remodeling processes, it is advisable to study the features of the hormonal profile in conditions of pathological scars. This will improve the efficiency of diagnosing of scar type and form a pathogenetic basis for the treatment of hypertrophic and keloid scars.

Aim

Aim. To identify the features of the hormonal profile in conditions of hypertrophic and keloid scars.

Materials and methods

Materials and methods. The clinical state of the scars and the hormonal profile (10 hormones) were studied in 90 women with hypertrophic, keloid and normotrophic scars (control). Blood was taken before treatment on the 5th–7th day of the menstrual cycle. The results were processed by non-parametric statistics (Me (Q25-Q75), U-test at p<0.05). Correlations between hormones were determined by the method of multiple regression at the coefficient of determination R2>0.7.

Results

Results. All patients with pathological scars showed a decrease in cortisol levels. Hypertrophic scars are characterized by an increase in the concentration of follicle-stimulating hormone, a decrease in the concentration of estradiol and testosterone. In patients with keloids, the concentration of growth hormone is increased, the levels of prolactin, luteinizing hormone are reduced. Regression analysis showed that the interdependence of hormones is maximally expressed in conditions of normotrophic scars, while hormones had 1-2 correlations in conditions of pathological scars. At the same time, the qualitative composition and direction of interrelations have changed.

Conclusion

Conclusion. Pathological scarring is characterized by a decrease in the level of cortisol in the blood, which is expressed in patients with keloid scars in combination with reduced prolactin. A weakening of hormonal interactions and an imbalance in the system of sex hormones were revealed in conditions of hypertrophic scars. and the increased production of growth hormone in combination with a stable interaction between steroidogenesis and a weakened adaptive ability took place in conditions of keloid scars.

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The authors declare that there are no conflicts of interest present.