bmjourБайкальский медицинский журналBaikal Medical Journal2949-0715Irkutsk State Medical University10.57256/2949-0715-2023-4-24-32bmjour-187Research ArticleНаучные обзоры литературыScientific literature reviewsАНТИОКСИДАНТЫ КАК ПОТЕНЦИАЛЬНЫЕ БИОМАРКЕРЫ СТАДИЙ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИANTIOXIDANTS AS POTENTIAL BIOMARKERS OF NONALCOHOLIC FATTY LIVER DISEASE STAGEShttps://orcid.org/0000-0002-7697-8609КравченкоСофья ДмитриевнаKravchenkoSofya D.boira.93@mail.ruhttps://orcid.org/0000-0002-0083-8845КозловаНаталия МихайловнаKozlovaNatalia M.ТириковаОлеся ВладимировнаTirikovaOlesya V.otirikova@mail.ruБахтаироваВера ИльиничнаBakhtairovaVera Il.bvi.38@mail.ruИркутский государственный медицинский университетРоссияIrkutsk State Medical UniversityRussian FederationФГБОУ ВО Иркутский государственный медицинский университет Минздрава РоссииРоссияIrkutsk State Medical UniversityRussian Federation202325122023242432Copyright © Кравченко С.Д., Козлова Н.М., Тирикова О.В., Бахтаирова В.И., 20232023Кравченко С.Д., Козлова Н.М., Тирикова О.В., Бахтаирова В.И.Kravchenko S., Kozlova N., Tirikova O., Bakhtairova V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.bmjour.ru/jour/article/view/187

Неалкогольная жировая болезнь печени — это сложное и многофакторное заболевание, связанное с множеством эпигенетических, генетических и экологических факторов, и его патогенез до сих пор не до конца изучен.  Неалкогольная жировая болезнь печени начинается с простого стеатоза и переходит в неалкогольный стеатогепатит, который характеризуется признаками окислительного стресса, увеличением активности перекисного окисления липидов, воспалением, фиброзом и апоптозом. В патогенезе неалкогольной жировой болезни печени важное значение имеет недостаток антиоксидантов, так как именно они обусловливают переход стеатоза в стеатогепатит при неалкогольной жировой болезни печени. При оценке прогрессирования заболевания и патологического состояния используют маркеры антиоксидантной защиты. В этой статье рассмотрены несколько ключевых биомаркеров антиоксидантной защиты, которые можно исследовать в клинической практике. Определение этих биомаркеров при неалкогольной жировой болезни печени может использоваться с диагностической целью.

Nonalcoholic fatty liver disease is a complex and multifactorial pathology associated with multiple epigenetic, genetic and environmental factors, and its pathogenesis is still not fully understood. Nonalcoholic fatty liver disease begins with simple steatosis and progresses to nonalcoholic steatohepatitis, which is characterized by signs of oxidative stress, increased lipid peroxidation activity, inflammation, fibrosis, and apoptosis. Antioxidant deficiency is important in the pathogenesis of nonalcoholic fatty liver disease, as it is they that cause the transition of steatosis to steatohepatitis in nonalcoholic fatty liver disease. Markers of antioxidant defense are used to assess disease progression and pathologic state. This article reviews several key biomarkers of antioxidant defense that can be investigated in clinical practice. Determination of these biomarkers in nonalcoholic fatty liver disease can be used for diagnostic purposes.

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The authors declare that there are no conflicts of interest present.